BAGONG PAG-ASANG HATID NG ANTIVIRAL NA TABLETA KONTRA COVID-19

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HABANG patagal nang patagal ang ating laban kontra COVID-19, lumalawak din ang kaalaman ng mga eskperto ukol sa pangontra sa virus.

Napakalaki na ng ipinagbago ng ating laban kontra COVID-19. Mula sa panahon na halos pinaralisa ng virus ang ekonomiya ng buong mundo, maraming bansa na ang muling nagbukas ng ekonomiya sa kabila ng hamon ng virus. Isa sa mga dahilan ng matinding pagbabago na ito ay ang pagkakaroon ng epektibong bakuna kontra COVID-19.  M­a­tapos ang pagkakaroon ng bakuna, ngayon ay isinasagawa naman ang clinical trial para sa COVID-19 antiviral pill.

Isang magandang balita ang lumabas kamakailan ukol sa pagsulong ng COVID-19 antiviral pill. Sa kasalukuyan, dalawang antiviral pill ang umabot na sa ikatlong bahagi ng kanilang isinasagawang trial. Ito ay ang Molnupiravir ng Merck & Co. with partner Ridgeback Biotherapeutics at ang PF-07321332 ng Pfizer.

Sa kasalukuyan, isang antiviral na gamot pa lamang ang binigyang pahintulot ng US Food and Drug Administration (US FDA) para gamitin bilang gamot kontra CO­VID-19. Ito ay ang Remdesivir ng Gilead Sciences. Ito ay isang uri ng gamot na itinuturok din sa pasyente habang ito ay nasa ospital. Paliwanag ng mga eksperto na ang CO­VID-19 ay nagsisimula bilang mild hanggang sa lumala ito at maging nakamamatay na sakit. Dahil sa ang Remdesivir ay kailangan iturok na parang bakuna, sa ospital lamang ito maaaring ibigay. Kadalasan, hindi na ito nagiging epektibo dahil sa lala ng kalagayan ng pasyente.

Ang pagkakaroon ng antiviral sa anyo ng tableta ay malaking tulong para sa mga ospital at maging sa pasyente. Mas madali itong maipamimigay sa mga pasyente kumpara sa Remdesivir na kailangang iturok ng sertipikadong nars. Sa ganitong paraan, maaari nang makakuha ng gamot ang pasyente bago pa man lumala ang sintomas nito na dala ng SARS-CoV-2, ang virus sa likod ng COVID-19.

Ang Molnupiravir na gawa ng Merck & Co. katulong ang Ridgeback Biotherapeutics ay gumagana sa pamamagitan ng panlilito nito sa polymerase ng Sars-Cov-2. Ang polymerase ay ang enzyme na bumubuo sa viral genome ng virus at siyang nagpaparami rito. Ayon sa antiviral expert at vice president of infectious disease discovery ng Merck, kahawig ng Molnupiravir ang polymerase ng virus kaya madali itong hahalo sa mga ito. Sa proseso ng pagpaparami ng virus, inaasahang hindi na ito makahahawa dahil sa paghina nito bilang resulta ng pagkahalo ng nasabing gamot.

Samantala, ang PF-07321332 naman ng Pfizer ay gumagana sa pamamagitan ng pagpigil nito sa pagpaparami ng pangunahing protease ng Sars-Cov-2. Ang protease ay ang enzyme na lulumusaw sa protina na bumubuo sa virus. Ang gamot na ito ay may kahalong ritonavir, ang gamot na karaniwang ginagamit ng mga indibidwal na positibo sa HIV upang mapanatiling mababa ang viral load.

Ang Pilipinas ay isa sa mga bansa kung saan isinasagawa ang ikatlong bahagi ng clinical trial para sa Molnupiravir. Dalawang ospital sa bansa, ang Lung Center of the Philippines (LCP) at ang Quirino Memorial Medical Center (QMMC), ang bahagi ng nasabing trial. Ayon sa clinical trial investigator ng LCP na si Dr. Virginia Delos Reyes, higit sa 100 bansa ang nakilahok sa trial, ngunit Pilipinas lamang ang bansang mula sa Timog Silangang Asya. Noong nakaraang buwan, hinikayat ng nasabing mga ospital na lumahok sa trial ang mga pasyenteng may  COVD-19 upang masubukan ang bisa ng nasabing gamot. Ang trial ay tinatayang aabot ng humigit kumulang pitong  buwan.

Upang maging kwalipikado sa nasabing trial, ang indibidwal ay dapat may edad 18 taong gulang pataas, positibo sa COVID-19 sa loob ng nakaraang limang araw, hindi pa nabakunahan, hindi naospital, may idineklarang hindi bababa sa isang comorbidity, at mayroong mild na sintomas ng COVID-19 gaya ng mga sumusunod: ubo, pamamaga ng  lalamunan, pagkabara ng ilong, runny nose, hirap sa paghinga, pananakit ng katawan, pakiramdam ng pagkapagod, temperaturang hindi bababa sa 38 degrees Celsius, pananakit ng ulo, pagkahilo, pagsusuka, pagtatae, pagkawala ng panlasa, at pagkawala ng pang-amoy.

Ayon sa country medical lead ng Merck, Sharp and Dohme sa bansa na si Dr. Mary Ann Escalona, napakahalaga ng gagampanang papel ng nasabing mga tableta kapag ito ay naaprubahan. Ito ang nakikita nyang paraan kung paano mapahihinto ang muli na namang pagtaas ng bilang ng bagong kaso ng COVID-19 kada araw at ang muling pagdami ng mga severe na kaso nito sa mga ospital. Dagdag pa ni Escalona na kasama sa pinag-aaralan sa isinasagawang trial ay ang magiging pagkilos ng nasabing gamot laban sa mga variant of concern kasama na ang Delta.

Ayon din kay Escalona, sa oras na mailimbag na ang datos mula sa trial, magsusumite na ito ng emergency use authorization (EUA) sa US FDA. Hihingi rin sila ng EUA sa Pilipinas kapag ang gamot ay inaprubahan na.

Isa itong kaabang-abang na balita para sa buong mundo. Bagaman matindi ang kasalukuyang hamon ng virus dahil sa patuloy na pagkalat ng Delta variant, nananatiling malaki ang pag-asa na hindi magtatagal ay mas malalabanan natin ito nang maayos. Kasabay ng pagsiguro na tuluy-tuloy ang programang pagbabakuna ng bansa upang mas maraming indibidwal ang mabigyan ng proteksiyon, ako ay naniniwala na sa tulong ng Molnupiravir at PF-07321332 ay mas maraming buhay ang maililigtas. Mas magiging madali rin para sa lahat ng bansa ang muling pagbubukas ng ekonomiya sa kabila ng pananatili ng virus.

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    Ada kelomang di dalamnya dan menjepit telinganya.

    Dia tidak pernah ingin kembali! LoL Saya tahu ini sepenuhnya di luar topik tetapi saya
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